Anti-Tocilizumab antibody

Anti-Tocilizumab is a chimeric rabbit/mouse antibody that specifically targets the human therapeutic antibody Tocilizumab. It consists of rabbit variable domains and mouse constant domains, mainly binding to free
Tocilizumab in samples.

Article number M9264
Product group Recombinant Antibody
Technique ELISA

General information

Description:

Anti-Tocilizumab is a chimeric rabbit/mouse anti-idiotypic antibody that specifically targets the human therapeutic antibody Tocilizumab. It consists of rabbit variable domains and mouse constant domains, and mainly binds to free Tocilizumab in samples.

Target:

Tocilizumab is a human IgG1/kappa antibody that recognizes the interleukin-6 receptor (IL-6R) and inhibits IL-6 signaling.

Application

Anti-Tocilizumab antibody has been evaluated in ELISA. Validation in other techniques is required by the user. It is recommended to test the antibody by titrating the product in the chosen technique, using appropriate negative and positive controls.

For research use only!

Figure

Figure 1: Titration of Tocilizumab to create a pharmacokinetic (PK) curve in bridging ELISA.

Anti-Tocilizumab antibody was used as capture (0.25 µg/ml) and detection (0.25 µg/ml) antibody in

sandwich assay format as described previously.(5) TCL=Tocilizumab

 

AntiBodyChain is the official worldwide distributor for the Sanquin/Essange Reagents products.

References

Find out more information about the scientific background of the product.

  1. Sebba A. Tocilizumab: The first interleukin-6-receptor inhibitor. American Journal of Health
    System Pharmacy. 2008; 65: 1413–1418. PMID:18653811.

  2. European Medicines Agency (EMA). Tyenne (tocilizumab).
    https://www.ema.europa.eu/en/medicines/human/EPAR/tyenne. 2023.

  3. European Medicines Agency (EMA). RoActemra (tocilizumab).
    https://www.ema.europa.eu/en/medicines/human/EPAR/roactemra. 2021.

  4. European Medicines Agency (EMA). Tofidence (tocilizumab).
    https://www.ema.europa.eu/en/medicines/human/EPAR/tofidence. 2024.

  5. Großerichter-Wagener C, Kos D, van Leeuwen A, Dijk L, Jeremiasse J, Loeff FC et al. Biased anti
    idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics. MAbs
    2020; 12. PMID:32887534.

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