Anti-Guselkumab antibody

Anti-Guselkumab is a chimeric rabbit/mouse anti-idiotypic antibody designed to specifically target the human therapeutic antibody Guselkumab. It features rabbit variable domains and mouse constant domains. This recombinant antibody primarily binds to free Guselkumab in samples.

Article number M9262
Product group Recombinant Antibody
Technique ELISA

General information

Description:

Anti-Guselkumab is a chimeric rabbit/mouse anti-idiotypic antibody specifically designed to target the human therapeutic antibody Guselkumab. It features rabbit variable domains and mouse constant domains, primarily binding to free Guselkumab in samples.

Target:

Guselkumab is a human IgG1/lambda antibody that recognizes the p19 subunit of interleukin-23 (IL-23) and blocks the IL-23 signaling pathway (1, 2).

Application

The Anti-Guselkumab antibody has been evaluated in ELISA. For other techniques, validation by the user is required. It is recommended to titrate the antibody in the chosen technique, using appropriate negative and positive controls.

For research use only!

Figure

Figure 1: Titration of Guselkumab to create a pharmacokinetic (PK) curve in bridging ELISA.

Anti-Guselkumab antibody was used as capture (0.25 µg/ml) and detection (0.125 µg/ml) antibody in

sandwich assay format, as described previously. (3) GSK= Guselkumab

 

AntiBodyChain is the official worldwide distributor for the Sanquin/Essange Reagents products.

References

Find out more information about the scientific background of the product.

 

  1. Nogueira M, Torres T. Guselkumab for the treatment of psoriasis – evidence to date. Drugs
    Context. 2019; 8.
  2. European Medicines Agency (EMA). Tremfya (guselkumab).
    https://www.ema.europa.eu/en/medicines/human/EPAR/tremfya. 2022.
  3. Großerichter-Wagener C, Kos D, van Leeuwen A, Dijk L, Jeremiasse J, Loeff FC et al. Biased
    anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics.
    MAbs 2020; 12. PMID:32887534.

 

 

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